General Cell Lines and Cell Cultures
Cell Applications Inc Rat Cardiac Fibroblast Total Kit, neonatal
Rat Cardiac Fibroblast Total Kit, neonatal:(R306-05n) Cryopreserved (RCF), 1 vial, neonatal(R116-500) Rat Fibroblast Growth Media, 500 ml(090K) Subculture Reagent Kit
Eurofins Discoverx PathHunter U2OS CXCR1 (IL8RA) β-Arrestin Cell Line, 2 vials. (93-0226C3)
The PathHunter CXCR1 (IL8RA) cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. CXCL8/IL8) based activation of CXCR1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged CXCR1 and EA-tagged β-Arrestin-2. Activation of CXCR1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Biochain Institute Inc Paraffin Tissue Section - Multiple Sclerosis Disease: Brain: Temporal Lobe, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's formalin fixed paraffin embedded (FFPE) tissue section line encompasses a large selection of tissue sections which are suitable for immunohistochemistry and in situ hybridization assays. The tissue sections are approximately 5 um thick. Each slide contains tissue from single human diseased sample. Documentation of tissues' clinical histories may be available upon request. For those customers who want to perform FFPE DNA and RNA isolation, BioChain can provide tissue section slices in tubes instead of mounting them on glass slides.
ATCC Aspergillus brasiliensis; WLRI 034(120); 6 x 0.3mL
ATCC 16404-MINI-PACK™ consists of 6 ready-to-use vials of ATCC 16404™ frozen in 200 μL of glycerol stock, eliminating the need to rehydrate and culture the strain prior to use. Each vial is provided with a 2-D barcode for easy storage and tracking, as well as peel-off labels for fast and reliable recordkeeping.
ATCC Human adenovirus 41; Strain: Tak (73-3544)
Human adenovirus 41 strain Tak (73-3544) is propagated in 293 [HEK-293] cells (ATCC CRL-1573). This strain was isolated in 1973 from the feces of a 14-month old human with gastroenteritis and was deposited by the National Institute for Public Health and the Environment, Netherlands. This product is whole-genome sequenced has applications in enteric and infectious disease research.
Biochain Institute Inc Frozen Tissue Section - Human Adult Normal: Adrenal, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's Frozen Tissue Slides are ideal for rapidly identifying cellular localization of RNA or protein. A single human adult normal tissue with 5-10 um thickness is mounted on a positively charged glass slide. The slides are fixed and dehydrated with acetone for consistent results with in situ hybridization and immunohistochemistry. More organs may be available upon request.
Eurofins Discoverx PathHunter PTGIR Total Internalization U2OS Cell Line, 2 vials. (93-0838C3)
The PathHunter PTGIR Total Internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line uses EFC technology to measure ligand-induced internalization of PTGIR via detection of localization to the early endosome. The included cell line overexpresses ProLink-tagged PTGIR and an EA-tagged early endosome protein. Upon ligand-induced receptor activation, resulting internalization of the PTGIR receptor to the early endosome leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx ChemiScreen CXCR6 Chemokine Receptor Stable Cell Line, 2 vials. (HTS054C)
The ChemiScreen CXCR6 Chemokine Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. CXCL16) based activation of CXCR6 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses CXCR6 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of CXCR6, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Biochain Institute Inc Paraffin Tissue Section - Human Skin Tumor: Fibrosarcoma, 5 sides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's formalin fixed paraffin embedded (FFPE) tissue section line encompasses a large selection of tissue sections which are suitable for immunohistochemistry and in situ hybridization assays. The tissue sections are approximately 5 um thick. Each slide contains tissue from a single human tumor. Documentation of tissues' clinical histories may be available upon request. For those customers who want to perform FFPE DNA and RNA isolation, BioChain can provide tissue section slices in tubes instead of mounting them on glass slides.
Genscript Corporation CHO-K1/OX1 Stable Cell Line
The orexin/hypocretin peptides orexin A and orexin B (also known as hcrt-1 and hcrt-2) are 33- and 28-amino acid peptides respectively They are preferentially expressed in hypothalamus The orexins have a range of physiological functions including feeding control energy metabolism neuroendocrine function modulation and sleep-wake cycle regulation The two orexin receptor subtypes OX1 and OX2 both mediate the action of orexin-A and orexin-B and couple efficiently through Gq/11 to activate phospholipase C and lead to elevation of intracellular calcium
Rockland Immunochemicals GUINEA PIG COMPLEMENT (fresh frozen) - C300-0010
Special processing techniques are used to yield products with high complement activity and low background cytotoxicity. Guinea Pig Complement is suitable for CFT and SRH.
Eurofins Discoverx ChemiScreen 5-HT6 Serotonin Receptor Membrane Preparation, 1 vial. (HTS111M)
The ChemiScreen 5-HT6 Serotonin Receptor Membrane Preparation is derived from proprietary stable recombinant cells to ensure high levels of HTR6 surface expression. ChemiScreen membrane preps can be used to screen for ligand binding affinities using a competitive radio-labeled ligand approach. Increased binding affinities will lead to higher radioactive signal. Membrane preps contain 1 mL of 1 mg/mL frozen membranes derived from a stably modified clonal cell line which was chosen for optimal receptor expression. For detailed product information, visit www.discoverx.com/membranepreps.
Eurofins Discoverx ChemiScreen MRGPRX1 Receptor Stable Cell Line, 2 vials. (HTS122C)
The ChemiScreen MRGPRX1 Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. BAM22) based activation of MRGPRX1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses MRGPRX1 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of MRGPRX1, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Eurofins Discoverx Ready-to-Assay CRF1 Corticotropin Releasing Factor Receptor Frozen Cells, 2 Vials of Cells. (HTS023RTA)
The Ready-to-Assay CRF1 Corticotropin Releasing Factor Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. CRH, sauvagine) based activation of CRHR1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses CRHR1 alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of CRHR1, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Cayman Chemical 9-cIs RetInal 1mg
A natural retinoid that is produced by oxidation of 9-cis retinol by cRDH; binds to CRBP-I, CRBP-II, and CRALBP (Kds = 8, 5, and 53.3 nM, respectively); inhibits differentiation of RCJ C5.18 chondrogenic cells into cartilage in vitro (IC50 = 8 nM); it rescues cone ERG responses in Irbp-/- mice (0.375 mg)